The diagnosis “burnout” is assuming ever greater significance. It not only affects people who are physically and emotionally exhausted after many years in the rat race, but increasingly frequently the younger “thirty something” generation. Social isolation and increased stress in working as well as personal life produces a malaise of depression, anxiety, and panic with multiple vegetative symptoms and various pain syndromes. In contrast to the standard medical therapy with antidepressants and tranquilizers, homeopathy can treat psychosomatic complaints gently, individually, and holistically. Using representative cases from renowned international authors, this issue of Spectrum shows homeopathic approaches to the treatment of the currently widespread illnesses of depression and especially burnout, offering tips for frequently indicated remedies and remedy groups, and describing typical patterns of healing.