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Immune reactions against a person's own body are often associated with severe pathology and ongoing destruction of the affected tissue. The standard treatment with immunosuppressants aims to impede this chronic process but may in turn cause permanent damage to the body. For many of those affected, homeopathy offers a possible solution to this dilemma. This issue of SPECTRUM examines questions such as what must be considered when treating autoimmune disease with homeopathy, how to coordinate this with conventional treatment, which methodological approaches are relevant, which groups of remedies are particularly suitable, and how to assess the response. The healing processes seen in the numerous cases presented – including vitiligo, rheumatoid arthritis, ankylosing spondylitis and chronic inflammatory bowel disease – demonstrate the potential of homeopathic treatment for autoimmune conditions. Our renowned international authors from a range of homeopathic schools present their approaches to this clinically severe problem.