For Samuel Hahnemann, the law of similars proved its value above all in the treatment of acute disease, sporadic fevers, and epidemics. Later on, modern medicine celebrated its greatest success in the area of infectious disease. Only now, with increasing distrust of multiple vaccinations and growing resistance to antibiotics, has there been a resurgence of interest in homeopathy. This issue of “Spectrum” investigates the power of homeopathy to deal with infection as well as other acute physical and psychological conditions, presents varying approaches for homeopathic treatment from casetaking via case analysis through to dosage, and describes mild to acutely threatening illness pictures with the relevant remedies and remedy families. The case studies are taken overwhelmingly from pediatric practice. We look at both the diagnosis of the genus epidemicus for flu epidemics as well as how to practically apply knowledge of the acute miasms.